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NEUROSURGICAL ANESTHESIOLOGY AND NEUROSCIENCE

Consensus Statement: First International Workshop on Anesthetics and Alzheimer’s Disease

Dmitri Baranov, MD^*, Philip E. Bickler, MD, PhD, Gregory J. Crosby, MD, Deborah J. Culley, MD, Maryellen F. Eckenhoff, PhD^*, Roderic G. Eckenhoff, MD^*, Kirk J. Hogan, MD, JD, Vesna Jevtovic-Todorovic, MD, PhD^||, András Palotás, MD, PhD^¶, Misha Perouansky, MD, Emmanuel Planel, PhD^#, Jeffrey H. Silverstein, MD^**, Huafeng Wei, MD, PhD^*, Robert A. Whittington, MD, Zhongcong Xie, MD, PhD, and Zhiyi Zuo, MD, PhD^||

From the *Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Department of Anesthesia, University of California San Francisco Medical Center, San Francisco, California; Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts; Department of Anesthesiology, University of Wisconsin, Madison, Wisconsin; ||Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia; ¶Asklepios-Med Bt, Szeged, Hungary; #Department of Pathology, Taub Institute for Alzheimer’s Disease Research, Columbia University Medical Center; **Department of Anesthesiology, Mount Sinai School of Medicine of New York University; Department of Anesthesiology, Columbia University Medical Center, New York City, New York; and Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Address correspondence and reprint requests to Roderic G. Eckenhoff, MD, University of Pennsylvania School of Medicine, Department of Anesthesiology and Critical Care, 305 John Morgan, 3620 Hamilton Walk, Philadelphia, PA 19104. Address e-mail to roderic.eckenhoff{at}uphs.upenn.edu.

Abstract

In order to review the current status of the potential relationship between anesthesia and Alzheimer’s disease, a group of scientists recently met in Philadelphia for a full day of presentations and discussions. This special article represents a consensus view on the possible link between Alzheimer’s disease and anesthesia and the steps required to test this more definitively.